I'm currently on a Wynncraft hiatus, but I decided to post something on forums just for the fun of it. Thus, I'm not sure if this concept has already been heavily utilized yet. Anyway, a good combo for a Poison+Melee build is Necrosis+Uranium Aegis+Writhing Growth. Necrosis is for poison and attack speed, Uranium Aegis is for poison and Plague, and Writhing Growth is for Main Attack Neutral Damage. The point of this build is to counter Writhing Growth's -atk speed and then add poison, along with a weapon with high attack speed. This allows very high dps builds for all classes: Tisaun's Proof: https://wynndata.tk/s/53wdsb (25.3k dps) Gert Swingpoke Cuttyrock: https://wynndata.tk/s/ug1o8l (26.9k dps) Wishing Star: https://wynndata.tk/s/5bghkj (25.7k dps) Cluster: https://wynndata.tk/s/z3265s (25.9k dps) Conference Call: https://wynndata.tk/s/hs80cm (25.7k dps) As you can see, the dps's don't vary much among classes, as the gear combinations don't really change much. Also, I'd like to note that you only need to use 2 E6 powders, as that's all you need for the max powder special, and more than 2 powders will barely/not increase the dps, due to Necrosis' debuffs. Of course, one negative of this concept is that you need a max atk speed necrosis for optimal building. EDIT: It seems this concept has been used widely already, as there is a term "cancelstack" (thanks Saya) that I'm seeing on other forum posts. I guess this post is basically just focusing on poison cancelstack then. I have edited the title to adapt to this.